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- AMBACTAM Inj. is an injectable antibacterial combination consisting of the semisynthetic antibiotic ampicillin sodium and the beta-lactamase inhibitor sulbactam sodium for intravenous and intramuscular administration.
Ampicillin acts through the inhibition of cell wall mucopeptide biosynthesis and has a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria.
Sulbactam effectively extends the antibiotic spectrum of ampicillin to include many bacteria normally resistant to it and to other beta-lactam antibiotics. Thus, AMBACTAM possesses the properties of a broad-spectrum antibiotic and a beta-lactamase inhibitor.
1 vial(750mg) contains 500 mg ampicillin as the sodium salt plus 250 mg sulbactam as the sodium sllt.
ㆍ Respiratory tract infections (including otitis meida, epiglottitis, sinusitis)
ㆍ Bacterial pneumonia
ㆍ Urinary tract infections and pyelonephritis
ㆍ Intra-Abdominal Infections (including peritonitis, cholecystitis, pelvic cellulites)
ㆍ Bacterial septicemia
ㆍ Skin and skin structure infections
ㆍ Bone and joint infection
ㆍ Gynecological Infections
ㆍ Prophylaxis of postoperative infection in abdominal, gynecological, and orthopaedic surgery.
AMBACTAM may be administered by either the IV or the IM routes. For IV administration, the dose can be given by slow intravenous injection over at least 10-15 minutes or can also be delivered, in greater dilutions with 50-100 mL of a compatible diluent as an intravenous infusion over 15-30 minutes.
AMBACTAM may be administered by deep intramuscular injection.
ㆍ Adult : 1.5 g† to 3 g‡ q6h. The total dose of sulbactam should not exceed 4 g/day.
ㆍ Newborn, infant, and child : Administration dose is 60~150 mg/kg/day in equally divided doses every 6 to 8 hours by IV infusion. For premature infant, 60~150 mg/kg/day in equally divided doses every 12 hours for 1 week after birth.
ㆍ In patients with impairment of renal function (CrCl < 30mL/min), it should be administrated less frequently.
ㆍ Prophylaxis of postoperative infection in orthopaedic surgery : 1.5g to 3g by IV or IM routes at the time of induction of anesthesia. Administer 3 to 4 times more if necessary.
† 1 g ampicillin as the sodium salt plus 0.5 g sulbactam as the sodium salt
‡ 2 g ampicillin as the sodium salt plus 1 g sulbactam as the sodium salt
- 1. 1st choice for the treatment of bacterial infections.
Combinations of sulbactam with ampicillin have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.
- 2. Low resistance potential for the presence of sulbactam.
- 3. Particular value as either a therapeutic or a prophylactic agent.
Broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria including beta-lactamase producing strains.