Active ingredient(s) and Contents

• Effective components

  • Glimepiride 2 mg

• Other

  • Lactose Hydrate, Sodium Starch Glycolate, Indigo carmine, Povidone, Microcrystalline Cellulose, Magnesium Stearate, Hydrated Ferric Oxide

Dosage and administration

• The dose will have to be adjusted on an individual basis This drug should be swallowed whole with more than half a glass of water. Orally administer once daily. Orally administer this drug before breakfast or the first meal. It is very important not to skip meals after taking this drug.
  
  1. Monotherapy
  
  • 1) The initial dose and dose determination
    In patients who have never received this medication before, the starting dose is 1 mg of glimepiride daily. If necessary, the dose is increased by 1 mg at one to two-week intervals. In general, there is little additional effect when a dose of 4 mg or more is administered, but some patients show better metabolic control by increasing the dose to 6 mg (or 8 mg). If there is no effect from daily administration of 4 mg, first, consider switching to insulin therapy, otherwise a combination therapy of insulin or other oral diabetes drugs should be considered.
    
  • 2) secondary dose adjustment
    As treatment progresses, diabetes control improves, which may reduce the need for this drug. Therefore, it may be necessary to reduce or stop taking this drug to avoid hypoglycemia. Dose adjustment should also be considered when weight loss, lifestyle changes, or other factors that may increase the risk of developing hypoglycemia or hyperglycemia occur.
    
  • 3) Switch from other oral hypoglycemic agents to glimepiride
    There is no exact dose correlation between this drug and other oral hypoglycemic agents. When switching to this drug after administering another oral hypoglycemic agent, it is recommended to follow the method suggested in the initial dose section. The administration can be started with 1 mg daily, and the dose can be adjusted at intervals of one or two weeks. The efficacy and persistence of previously administered drugs should be considered.
    
  • 4) Dose adjustment
    While taking this drug, blood and/or urinary glucose levels should be measured regularly, and it is also recommended to regularly measure glycosylated hemoglobin (HbA1c) levels. In general, hypoglycemia is immediately controlled by sugar intake directly. When sulfonylureas are administered, despite initial coping success, hypoglycemia can recur. Therefore, the patient must be carefully observed. In the case of severe hypoglycemia, prompt treatment and follow-up by a doctor are required, and treatment/ hospitalization is required.
  
  2. Combination therapy
  • 1) Combination therapy with insulin
    A combination therapy of this drug and insulin is used in patients with secondary failure, and when fasting blood sugar (FBG) exceeds 150 mg/dL, combination therapy with insulin is used. Administer 8 mg of this drug once daily with the first meal, and insulin starts at low doses and increases at approximately weekly intervals based on fasting blood glucose measurements. Once stabilized, capillary blood glucose should be monitored every day as possible. While taking this drug, blood glucose levels should be measured regularly, and it is also recommended to regularly measure glycosylated hemoglobin (HbA1c) levels.
    
  • 2) Combination therapy with metformin
    In patients not adequately controlled with the maximum daily dose of Glimepiride, additional metformin can be considered. There is reported clinical data about a combination therapy of metformin and sulfonylurea formulation (glibenclamide, glipizide, chlorpropamide, tolbutamide and etc.). In combination therapy with this drug and metformin, the target blood glucose can be achieved by adjusting the dose of each drug. However, efforts should be made to determine the minimum effective dose of each drug for glucose control. There is an increased risk of hypoglycemia with the co-administration of this drug and metformin. Adequate care should be taken.

Storage and handling

• 
  Airtight container, keep at room temperature (1~30°C)