Active ingredient(s) and Contents

• Effective components

  • Futhan Inj.: Nafamostat Mesilate 10 mg
    Futhan Inj. 50: Nafamostat Mesilate 50 mg

• Other

  • D-Mannitol, Succinic Acid

Dosage and administration

• A. Method of administration

  • 1. For improvement of acute symptoms of pancreatitis.
    Usually, 10mg of nafamostat mesilate dissolved in 500ml of 5% glucose solution is drip-infused intravenously over about 2 hours, once or twice a day. The dosage can be individually adjusted according to the severity of symptoms.
    
    
  • 2. Disseminated Intravascular Coagulation (DIC).
    Usually, one-day dose dissolved in 1000ml of 5% glucose solution is drip-infused intravenously over 24 hours at the rate of 0.06~0.20mg/kg/hr as nafamostat mesilate.
    
    
  • 3. To prevent coagulation of blood during extracorporeal blood circulation in patients with bleeding complications or bleeding tendency.
    For priming, wash and fill the blood route with 500ml of containing 20mg of nafamostat mesilate. After beginning of extracorporeal circulation, inject continuously 20~50mg/hr of nafamostat mesilate dissolved in 5% glucose solution into anticoagulant injection line. The dosage can be individually adjusted according to the severity of symptoms.
    In clinical results, the average dose was 35 mg every hour.
    
    
  
  

  B. Preparation of injection solution

  In order to administer this drug, the injection solution is prepared in the following order.

  • 1. Improve acute symptoms of pancreatitis
    
  • 1) Add 1 mL or more of 5% glucose injection or water for injection to a 10 mg vial and completely dissolve.
    
  • 2) The dissolved solution is mixed with 500 mL of 5% glucose injection solution.
    
    
  • 2. Disseminated Intravascular Coagulation (DIC)
    
  • 1) Add 1 mL or more / 5 mL or more of 5% glucose injection or water for injection to a 10 mg vial / a 50 mg vial, and completely dissolve.
    
  • 2) The dissolved solution is mixed with 1,000 mL of 5% glucose injection solution.
    
    
  • 3. Prevent clotting of hemoperfusion during extracorporeal circulation in patients with hemorrhagic lesion or with a high risk of bleeding
    
  • 1) Washing · filling into the blood circuit
    (1) Add 1 mL or more / 5 mL or more of 5% glucose injection or water for injection to a 10 mg vial / a 50 mg vial, and completely dissolve.
    (2) A dissolution solution containing 20 mg of nafamostat mesilate is mixed with 500 mL of normal saline.
    
  • 2) During extracorporeal circulation
  • (1) Add 1 mL or more / 5 mL or more of 5% glucose injection or water for injection to a 10 mg vial / a 50 mg vial, and completely dissolve.
  • (2) The dissolved solution is diluted with 5% glucose injection solution according to the dose of the anticoagulant continuous injector.
  • 4. Caution when dissolving
    • Do not directly add a solution containing normal saline and inorganic salts to the vial, as white turbidity or crystals may precipitate.

Storage and handling

• Light resistant and hermetic container, keep at room temperature (1~30°C)